Bundgaard A, Rasmussen F V, Madsen L
Allergy. 1980 Dec;35(8):639-45. doi: 10.1111/j.1398-9995.1980.tb02016.x.
Eighteen adult asthmatics took part in a double-blind crossover study comparing the effect on exercise-induced asthma (EIA) of pretreatment with aerosolized 1) disodium cromoglycate (DSCG), 2) ipratropium bromide (IPTB), 3) fenoterol, 4) DSCG + IPTB and 5) saline. EIA was completely blocked by pretreatment with the beta 2-agonist, fenoterol. The protective effect of nebulized DSCG and IPTB given alone could not be distinguished from that of isotonic saline. The combination of DSCG and IPTB reduced the post-exercise bronchoconstriction more than any of the two drugs given separately. Thirteen of the 18 patients went on to a double-blind cross-over study of the effect on EIA of pretreatment with the usually recommended dosages off salbutamol, theophylline and their combination administered as pulverized tablets. Seven patients were withdrawn from this part of the study because of side-effects, and in the remaining six none of the oral pretreatments could be distinguished from placebo, despite serum theophylline concentrations within or above the commonly recommended therapeutical range.
18名成年哮喘患者参与了一项双盲交叉研究，该研究比较了雾化吸入以下物质预处理对运动诱发性哮喘（EIA）的影响：1）色甘酸钠二钠（DSCG）、2）异丙托溴铵（IPTB）、3）非诺特罗、4）DSCG + IPTB以及5）生理盐水。β2受体激动剂非诺特罗预处理可完全阻断运动诱发性哮喘。单独雾化吸入DSCG和IPTB的保护作用与等渗盐水无法区分。DSCG和IPTB联合使用比单独使用这两种药物中的任何一种更能减轻运动后支气管收缩。18名患者中的13名继续参与了一项双盲交叉研究，该研究旨在比较通常推荐剂量的沙丁胺醇、茶碱及其以分散片形式联合使用预处理对运动诱发性哮喘的影响。由于副作用，7名患者退出了该部分研究，在其余6名患者中，尽管血清茶碱浓度在通常推荐的治疗范围内或高于该范围，但口服预处理与安慰剂之间无法区分。
