Kay J M, Suyama K L, Keane P M
Am Rev Respir Dis. 1981 Apr;123(4 Pt 1):454-8. doi: 10.1164/arrd.1981.123.4.454.
We studied the effect of continuous and intermittent normoxia for 6 and 20 wk on the muscularization of pulmonary arterioles in rats with chronic hypoxic hypertension. After 4 wk in a hypobaric chamber (380 mm Hg) the proportion of small pulmonary blood vessels with 2 elastic laminae (PVTEL) was 21.57 +/- 14.86% (SD) (n = 10) compared with 3.66 +/- 1.86% in 10 untreated control animals. Recovery using continuous normoxia and intermittent normoxia 16 h/day for 6 wk caused a reduction in PVTEL to 8.45 +/- 4.09% (n = 6) and 7.16 +/- 6.96% (n = 6), respectively. Right ventricular hypertrophy (RVH) was reversed by recovery using continuous normoxia for 6 wk but was unaffected by intermittent normoxia (16 h/day). Intermittent normoxia 8 h/day for 6 wk did not reduce the PVTEL or RVH. Continuous normoxia for 20 wk reversed the muscularization of small pulmonary vessels (PVTEL, 3.86 +/- 3.57%; n = 4) and RVH. Intermittent normoxia (16 h/day) for 20 wk significantly diminished the PVTEL to 7.39 +/- 3.73% (n = 5) but did not reduce RVH. Prolonged continuous normoxia slowly reversed the pulmonary hypertension, RVH, pulmonary vascular lesions, and polycythemia induced by chronic hypoxia. Intermittent normoxia (16 h/day) diminished the pulmonary vascular lesions but not the pulmonary hypertension, RVH, and polycythemia. Intermittent normoxia (8 h/day) was ineffective.
我们研究了持续常氧和间歇常氧分别作用6周和20周对慢性低氧性高血压大鼠肺小动脉肌化的影响。在低压舱（380 mmHg）中饲养4周后，具有2层弹性膜的小肺血管比例（PVTEL）在10只大鼠中为21.57±14.86%（标准差）（n = 10），而10只未处理的对照动物中该比例为3.66±1.86%。持续常氧恢复以及每天16小时间歇常氧恢复6周后，PVTEL分别降至8.45±4.09%（n = 6）和7.16±6.96%（n = 6）。持续常氧恢复6周可逆转右心室肥厚（RVH），但间歇常氧（每天16小时）对其无影响。每天8小时间歇常氧6周并未降低PVTEL或RVH。持续常氧20周可逆转小肺血管的肌化（PVTEL，3.86±3.57%；n = 4）和RVH。每天16小时间歇常氧20周可使PVTEL显著降至7.39±3.73%（n = 5），但未降低RVH。长时间持续常氧可缓慢逆转慢性低氧诱导的肺动脉高压、RVH、肺血管病变和红细胞增多症。间歇常氧（每天16小时）可减轻肺血管病变，但对肺动脉高压、RVH和红细胞增多症无效。间歇常氧（每天8小时）无效。
