Skin reactions to carbamazepine.

Three patients with a generalized eruption caused by carbamazepine are described. Two reactions were eczematous, and one was lichenoid in nature. Oral challenge with the drug reproduced the skin disorder in each of these patients. Immunofluorescence microscopy studies demonstrated that in four out of six subjects taking carbamazepine, there were deposits of immunoglobulins in the skin.