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卡马西平在一名患有严重血清病的患者中诱导产生抗卡马西平抗体。

Anticarbamazepine antibody induced by carbamazepine in a patient with severe serum sickness.

作者信息

Hosoda N, Sunaoshi W, Shirai H, Bando Y, Miura H, Igarashi M

机构信息

Department of Paediatrics, Kitasato University School of Medicine, Kanagawa, Japan.

出版信息

Arch Dis Child. 1991 Jun;66(6):722-3. doi: 10.1136/adc.66.6.722.

DOI:10.1136/adc.66.6.722
PMID:2053795
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1793138/
Abstract

Anticarbamazepine antibody was detected in a patient who had clinical signs of serum sickness induced by carbamazepine. Skin rash, fever, oedema, and lymphadenopathy are classic signs of severe adverse reaction, but although immunological hypersensitivity is thought to be a contributory factor, the presence of anticarbamazepine antibody has not previously been reported to our knowledge.

摘要

在一名有卡马西平所致血清病临床症状的患者中检测到了抗卡马西平抗体。皮疹、发热、水肿和淋巴结病是严重不良反应的典型症状,尽管免疫超敏反应被认为是一个促成因素,但据我们所知,此前尚未有抗卡马西平抗体存在的报道。

相似文献

1
Anticarbamazepine antibody induced by carbamazepine in a patient with severe serum sickness.卡马西平在一名患有严重血清病的患者中诱导产生抗卡马西平抗体。
Arch Dis Child. 1991 Jun;66(6):722-3. doi: 10.1136/adc.66.6.722.
2
Immunosuppressive factors detected during convalescence in a patient with severe serum sickness induced by carbamazepine.在一名由卡马西平诱发的严重血清病患者恢复期检测到的免疫抑制因子。
Int Arch Allergy Immunol. 1993;100(4):378-81. doi: 10.1159/000236442.
3
An immunodominant haptenic epitope of carbamazepine detected in serum from patients given long-term treatment with carbamazepine without allergic reaction.在长期接受卡马西平治疗且无过敏反应的患者血清中检测到的卡马西平免疫显性半抗原表位。
J Clin Immunol. 1992 Sep;12(5):335-40. doi: 10.1007/BF00920790.
4
Severe adverse reaction to carbamazepine: significance of humoral and cellular reactions to the drug.卡马西平的严重不良反应:对该药物体液和细胞反应的意义。
Neuropediatrics. 1992 Oct;23(5):272-5. doi: 10.1055/s-2008-1071357.
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Serum sickness-like syndrome associated with minocycline therapy.与米诺环素治疗相关的血清病样综合征。
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Lymphocyte-stimulation tests and patch tests to carbamazepine hypersensitivity.淋巴细胞刺激试验及卡马西平超敏反应的斑贴试验。
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[Cefaclor therapy followed by serum sickness-like symptoms].头孢克洛治疗后出现血清病样症状
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引用本文的文献

1
Anticonvulsant hypersensitivity syndrome in children: incidence, prevention and management.儿童抗惊厥药超敏反应综合征:发病率、预防与管理
CNS Drugs. 2002;16(3):197-205. doi: 10.2165/00023210-200216030-00006.
2
An immunodominant haptenic epitope of carbamazepine detected in serum from patients given long-term treatment with carbamazepine without allergic reaction.在长期接受卡马西平治疗且无过敏反应的患者血清中检测到的卡马西平免疫显性半抗原表位。
J Clin Immunol. 1992 Sep;12(5):335-40. doi: 10.1007/BF00920790.

本文引用的文献

1
Allergic reactions to drugs and biologic agents.对药物和生物制剂的过敏反应。
JAMA. 1982 Nov 26;248(20):2637-45.
2
Carbamazepine. Pharmacology and clinical uses.
Acta Neurol Scand Suppl. 1981;88:1-202.
3
Skin reactions to carbamazepine.
Arch Dermatol. 1981 May;117(5):273-5.
4
Clinical spectrum of allergic and pseudoallergic drug reactions.
J Allergy Clin Immunol. 1984 Oct;74(4 Pt 2):558-66. doi: 10.1016/0091-6749(84)90107-6.
5
The role of metabolism in the immunogenicity of drugs: production of antibodies to a horseradish peroxidase generated conjugate paracetamol.代谢在药物免疫原性中的作用:针对辣根过氧化物酶生成的对乙酰氨基酚缀合物产生抗体。
Clin Exp Immunol. 1985 Aug;61(2):224-31.
6
Treatment with carbamazepine: children.卡马西平治疗:儿童。
Adv Neurol. 1975;11:237-48.
7
Metabolism and Pharmacolinetics of Carbamazepine.卡马西平的代谢与药代动力学
Drug Metab Rev. 1975;4(1):97-113. doi: 10.3109/03602537508993750.
8
Deposits of plasma proteins in the skin during treatment with carbamazepine and diphenylhydantoin.在使用卡马西平和苯妥英治疗期间皮肤中血浆蛋白的沉积。
Acta Med Scand. 1977;202(1-2):113-7. doi: 10.1111/j.0954-6820.1977.tb16795.x.