[Ultrastructural bases of myocardial metabolic disorders under physical loads in alpine adaptation].

Ultrastructural and metabolic manifestations of adaptation mechanisms of myocardium of white rats were studied in highlands (Tuya-Ashu pass, 3200 meter above sea level) upon treatment with dosed physical loading. The development of processes of myocardial adaptation to highland hypoxia was found to be step-wise and manifested by the development of destructive and compensatory-adaptative processes. Physical loads in the early period of adaptation resulted in destruction and loss of mitochondria and other intracellular organelles. Prolonged effect of physical loads and hypoxia was accompanied by mobilization of protein synthesis, activation of metabolic enzymes and new formation of mitochondria and myofibrills.