Shmerling M D, Filiushina E E, Buzueva I I
Biull Eksp Biol Med. 1982 Nov;94(11):119-22.
Experiments on rats exposed to intense exercise and high-altitude hypoxia have shown the reduction in physical efficiency and in the training effect of muscle loads as compared to the same characteristics examined under the conditions of plain. Electron microscopy of rat skeletal muscle fibers has discovered significant changes in their ultrastructure. Morphometric analysis of the same changes has shown a reduction in the relative volume of mitochondria, an increase in the relative volume of sarcoplasmic reticulum an abrupt fall of the glycogen reserves in the early stages of experiment with a further tendency towards the normalization of this characteristic. The changes described were followed by focal destructive-degenerative abnormalities in the energy and in the contractile-myofibrillar apparatuses.
对暴露于高强度运动和高原缺氧环境的大鼠进行的实验表明，与在平原条件下检测到的相同特征相比，大鼠的体力效率和肌肉负荷训练效果有所降低。对大鼠骨骼肌纤维的电子显微镜检查发现其超微结构有显著变化。对这些相同变化的形态计量分析表明，线粒体的相对体积减少，肌浆网的相对体积增加，在实验早期糖原储备急剧下降，随后这一特征有进一步趋于正常化的趋势。上述变化之后，能量和收缩肌原纤维装置出现局灶性破坏 - 变性异常。
