Isaksson-Forsén G, Elgjo K, Burton D, Iversen O H
Cell Biol Int Rep. 1981 Feb;5(2):195-9. doi: 10.1016/0309-1651(81)90028-x.
The epidermal G2 chalone was partially purified from hairless mouse skin extracts by means of chromatography and ultrafiltration and tested in vivo on hairless mouse epidermis. The active component had a molecular weight of less than 10,000 daltons. It significantly but had no effect on epidermal cells at the G1/S transition. Extracts from mouse spleen or skeletal muscle treated in the same way as the skin extracts had no inhibitory effect on epidermal G2 cells.
通过色谱法和超滤法从无毛小鼠皮肤提取物中部分纯化出表皮G2抑素，并在无毛小鼠表皮上进行体内试验。活性成分的分子量小于10,000道尔顿。它对处于G1/S期转换的表皮细胞有显著影响，但对其没有作用。以与皮肤提取物相同的方式处理的小鼠脾脏或骨骼肌提取物对表皮G2细胞没有抑制作用。
