Levine B S, Henry M C, Port C D, Rosen E
Drug Chem Toxicol. 1980;3(2):201-12. doi: 10.3109/01480548009108283.
Single intravenous doses of CDF1 mice, and single and five daily intravenous treatment schedules in beagle dogs and rhesus monkeys were used to evaluate the toxicity of Streptozotocin (SZN). The major target organs in the three species were liver, kidney, lymphoid tissue and pancreatic islet beta cells. Moderate bone marrow depression and gastrointestinal toxicity were observed in the large animal species after lethal doses. Monkeys were less sensitive than the dog to the hepatotoxic effects of SZN and clinical signs of liver dysfunction were more severe in dogs after multiple doses. Microscopic lesions in the renal proximal convoluted tubules were present in the three species; these lesions appeared to be irreversible for dogs. The toxic effect on the endocrine pancreas was manifest by hyperglycemia, glucosuria, islet atrophy and beta cell degranulation. Multiple dose regimens were less toxic than single doses in dogs and monkeys in terms of the total dose received.
采用向CDF1小鼠单次静脉注射，以及对比格犬和恒河猴进行单次和每日5次静脉注射的给药方案，来评估链脲佐菌素（SZN）的毒性。这三个物种的主要靶器官为肝脏、肾脏、淋巴组织和胰岛β细胞。在给予致死剂量后，大型动物物种出现了中度骨髓抑制和胃肠道毒性。猴子对SZN的肝毒性作用比犬更不敏感，多次给药后犬的肝功能障碍临床症状更严重。这三个物种的肾近端曲管均出现了微观病变；这些病变对犬似乎是不可逆的。对内分泌胰腺的毒性作用表现为高血糖、糖尿、胰岛萎缩和β细胞脱颗粒。就接受的总剂量而言，多次给药方案在犬和猴身上的毒性低于单次给药。
