de la Caffinière J Y, Mignot M, Bruch J M
Rev Chir Orthop Reparatrice Appar Mot. 1981;67(1):47-58.
104 patients who had been subjected to an orthopaedic procedure such as total hip prosthesis, knee prosthesis, or upper femoral osteotomy, have been studied by pre- and post-operative phlebographs. Calcium heparinate was given systematically after operation. It was noted that despite this regime, half of the patients showed thrombosis. The "dangerous" clot was situated in a main venous trunk and was unattached. Out of 79, 40 clots were said "dangerous". Four emboli were observed, of which one was fatal. Total hip prostheses were less dangerous than knee prostheses or osteotomies. A popliteal clot was more dangerous if traction was used post-operatively, and if the dose of heparin was only a preventive dose. Curative doses limited the extent of clots formed and decreased the likelihood of migration provided medication was started early. Pre-operative injection of heparin 2 hours before operation did not decrease the number of clots. Some other risks were also analysed. It was noted that early re-operation was accompanied by a very high risk. In such cases, preventive occlusion of the inferior vena cava may be justified.
104名接受过诸如全髋关节置换术、膝关节置换术或股骨上段截骨术等骨科手术的患者,已通过术前和术后静脉造影进行了研究。术后系统给予肝素钙。值得注意的是,尽管采取了这种治疗方案,但仍有一半的患者出现了血栓形成。“危险”血栓位于主要静脉干且未附着。在79例中,40个血栓被认为是“危险的”。观察到4例栓子,其中1例致命。全髋关节置换术比膝关节置换术或截骨术危险性小。如果术后使用牵引,且肝素剂量仅为预防剂量,腘静脉血栓则更危险。如果早期开始用药,治疗剂量可限制血栓形成范围并降低迁移的可能性。术前2小时注射肝素并不能减少血栓数量。还分析了其他一些风险。值得注意的是,早期再次手术伴随着非常高的风险。在这种情况下,预防性下腔静脉闭塞可能是合理的。