Mori T
Acta Obstet Gynaecol Jpn. 1981 Feb;33(2):285-91.
We have investigated the spleen cell response to Con A in terms of the blastoformation response of lymphocytes, which is known to be an index of the nonspecific immune response of the host organism, in various stages of experimentally induced lesions of the murine uterine cervix. It was found that, under the controlled conditions of the present experiment, suppressor T cells are induced in histological samples exhibiting AT III or severer lesions, which correspond to carcinoma of the uterine cervix. This fact suggests the possibility that antibody synthesis is suppressed. In animals administered the immunopotentiator, ATSO, the development of malignant lesions of the uterine cervix was suppressed, the induction of suppressor T cells was suppressed and the response of spleen cells to Con A was found to decrease.
我们在小鼠子宫颈实验性诱导损伤的各个阶段，就淋巴细胞的母细胞形成反应（已知其为宿主生物体非特异性免疫反应的指标）方面，研究了脾细胞对刀豆蛋白A的反应。结果发现，在本实验的可控条件下，在表现出III级或更严重病变（相当于子宫颈癌）的组织学样本中诱导出了抑制性T细胞。这一事实提示了抗体合成被抑制的可能性。在给予免疫增强剂ATSO的动物中，子宫颈恶性病变的发展受到抑制，抑制性T细胞的诱导受到抑制，并且发现脾细胞对刀豆蛋白A的反应降低。
