Research on experimentally induced cervical cancers and the reactivity of spleen cells to Con A.

We have investigated the spleen cell response to Con A in terms of the blastoformation response of lymphocytes, which is known to be an index of the nonspecific immune response of the host organism, in various stages of experimentally induced lesions of the murine uterine cervix. It was found that, under the controlled conditions of the present experiment, suppressor T cells are induced in histological samples exhibiting AT III or severer lesions, which correspond to carcinoma of the uterine cervix. This fact suggests the possibility that antibody synthesis is suppressed. In animals administered the immunopotentiator, ATSO, the development of malignant lesions of the uterine cervix was suppressed, the induction of suppressor T cells was suppressed and the response of spleen cells to Con A was found to decrease.