兔抗EL4血清。一种对一群小鼠抑制细胞具有特异性的试剂。
Rabbit anti-EL4 serum. A reagent with specificity for a population of murine suppressor cells.
作者信息
Al-Sakkaf L, Cooke A, Hutchings P, Jones B
出版信息
Immunology. 1979 Oct;38(2):375-83.
Antisera against the C57B1 (H-2b) mouse lymphoma, EL4 were prepared in rabbits. After absorption with mouse liver, red cells and thymocytes the antisera appeared to be cytotoxic for a subpopulation of peripheral T cells. The absorbed antisera blocked the immunosuppressor function of Con A-stimulated splenic lymphocytes, but was unreactive against Con A-stimulated and allogeneically primed cytotoxic cells, or helper T cells. Consequently, heteroantiserum against EL4 may provide a useful reagent for the differentiation of cytotoxic from suppressor T-cell subsets.
用兔制备了抗C57B1（H-2b）小鼠淋巴瘤EL4的抗血清。在用小鼠肝脏、红细胞和胸腺细胞吸收后，该抗血清似乎对一群外周T细胞具有细胞毒性。吸收后的抗血清阻断了刀豆蛋白A刺激的脾淋巴细胞的免疫抑制功能，但对刀豆蛋白A刺激的和同种异体致敏的细胞毒性细胞或辅助性T细胞无反应。因此，抗EL4异种抗血清可能为区分细胞毒性T细胞亚群和抑制性T细胞亚群提供一种有用的试剂。
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