Lambert D, Fort M, Legoux A, Chapuis J L
Ann Dermatol Venereol. 1980;107(11):1035-41.
The sudden occurrence and rapid increase in size and number of seborrheic keratoses is considered to be a symptom of internal malignancy. But many authors did not fully agree with this finding. We report two cases respectively associated, the first with a mycosis fongoides, the second with a bronchial squamous cell carcinoma. These observations are compared with thin cases previously published in the dermatological literature (13 patients). According to Dantzig the commonest associated malignancy is an adenocarcinoma, and the most frequent site the stomach. But there are also report of acute leukemia, mycosis fongoides, Sézary and lymphocytic lymphoma. The mechanism of the simultaneous growth of the lesions remains unknown and may be purely coincidental. Other case reports and several criteria still to be defined are needed before we accept this symptom as a malignancy marker.
脂溢性角化病的突然出现以及大小和数量的迅速增加被认为是内部恶性肿瘤的一种症状。但许多作者并不完全认同这一发现。我们报告了两例分别相关的病例，第一例与蕈样肉芽肿有关，第二例与支气管鳞状细胞癌有关。将这些观察结果与皮肤病学文献中先前发表的病例（13例患者）进行了比较。根据丹齐格的说法，最常见的相关恶性肿瘤是腺癌，最常见的部位是胃。但也有急性白血病、蕈样肉芽肿、塞扎里综合征和淋巴细胞淋巴瘤的报告。病变同时生长的机制仍然未知，可能纯属巧合。在我们将这种症状视为恶性肿瘤标志物之前，还需要其他病例报告和一些有待确定的标准。
