Sperry K, Wall J
Cancer. 1980 May 1;45(9):2434-7. doi: 10.1002/1097-0142(19800501)45:9<2434::aid-cncr2820450932>3.0.co;2-m.
The sign of Leser-Trélat, the sudden appearance of multiple seborrheic keratoses in conjunction with an internal malignancy, is very uncommon. A case involving a patient who had undergone resection of an adenocarcinoma of the sigmoid colon followed ten years later by the development of an adenocarcinoma of the stomach with exhibition of the sign of Leser-Trélat is presented. A summary of reported cases, along with a discussion of the sign, is provided. This is the first reported case of a patient presenting with the sign of Leser-Trélat along with a second primary malignancy.
Leser-Trélat征，即多发性脂溢性角化病与体内恶性肿瘤同时突然出现的情况非常罕见。本文介绍了一例患者，该患者曾接受乙状结肠癌切除术，十年后发生胃癌并出现Leser-Trélat征。文中提供了已报道病例的总结以及对该体征的讨论。这是首例报道的出现Leser-Trélat征并伴有第二种原发性恶性肿瘤的患者。
