Larsen A
Acta Physiol Scand. 1978 Mar;102(3):357-63. doi: 10.1111/j.1748-1716.1978.tb06082.x.
Muscle action potentials and miniature end-plate potential frequency were studied in different concentrations of pindolol, d- and l-propranolol and sotalol using intracellular microelectrode recording from rat phrenic nerve-diaphragm preparations. d-and l-propranolol at concentrations of 10 to 40 mg/l and pindolol at 20 to 100 mg/l slowed down the rate of rise, prolonged rise and half-decay times and reduced the overshoot of the muscle action potentials. Sotalol had similar effects but only at higher concentrations (100 to 200 mg/l). The drugs had no effect on the increase in the miniature end-plate potential frequence obtained with depolarization by increased extracellular potassium concentration.
采用细胞内微电极记录法，在大鼠膈神经-膈肌标本上，研究了不同浓度的吲哚洛尔、d-和l-普萘洛尔以及索他洛尔对肌肉动作电位和微小终板电位频率的影响。浓度为10至40mg/l的d-和l-普萘洛尔以及20至100mg/l的吲哚洛尔减慢了肌肉动作电位的上升速率，延长了上升和半衰减时间，并降低了动作电位的超射值。索他洛尔也有类似作用，但仅在较高浓度（100至200mg/l）时出现。这些药物对细胞外钾离子浓度升高去极化所致的微小终板电位频率增加没有影响。
