Nirmala G, Brahmayya Sastry P
Arch Int Pharmacodyn Ther. 1979 Apr;238(2):196-205.
The action of beta-adrenergic blockers on neuromuscular function has been reexamined using a recent beta-blocker pindolol (Visken), along with propranolol and procaine, on three isolated skeletal muscle preparations from the same species, frog: hyoglossus muscle stimulated through hypoglossal nerve, rectus abdominis and hyoglossus muscles using acetylcholine as an agonist. The depressant action of pindolol and propranolol was found to be non-competitive. The three test-drugs potentiated the depressant actions of d-tubocurarine and succinylcholine. The results point to a local anaesthetic mode of action of beta-blockers. Pindolol which is 10-40 times more potent than propranolol as a beta-blocker but now shown to be only one-fourth as potent in its neuro-muscular depressant action, may have lesser neuro-muscular side effects than propranolol in patients receiving high doses of propranolol for antihypertensive therapy.
使用近期的β受体阻滞剂吲哚洛尔（心得静）以及普萘洛尔和普鲁卡因，对来自同一物种青蛙的三种离体骨骼肌标本进行研究，重新审视了β肾上腺素能阻滞剂对神经肌肉功能的作用：通过舌下神经刺激的舌骨舌肌、使用乙酰胆碱作为激动剂的腹直肌和舌骨舌肌。发现吲哚洛尔和普萘洛尔的抑制作用是非竞争性的。这三种受试药物增强了筒箭毒碱和琥珀酰胆碱的抑制作用。结果表明β受体阻滞剂的作用方式为局部麻醉。吲哚洛尔作为β受体阻滞剂的效力比普萘洛尔强10 - 40倍，但现在显示其神经肌肉抑制作用仅为普萘洛尔的四分之一，在接受大剂量普萘洛尔进行抗高血压治疗的患者中，吲哚洛尔的神经肌肉副作用可能比普萘洛尔小。
