Kripke M L, Morison W L, Parrish J A
J Invest Dermatol. 1981 Jun;76(6):445-8. doi: 10.1111/1523-1747.ep12521067.
Skin tumors induced in mice by chronic exposure to UVB radiation are often highly antigenic and regress when transplanted into normal syngeneic animals, but grow progressively in immunosuppressed mice. Exposure of mice to subtumorigenic doses of UVB radiation can abolish this immunologic rejection phenomenon. In this study, we have investigated the effects of treatment with 8-methoxypsoralen plus UVA radiation (PUVA) on the rejection of antigenic UVB-induced tumors. PUVA treatment, with either topical or systemic administration of the psoralen, did not alter the normal process of rejection of UVB-induced tumors. Mice treated with both minimally and markedly phototoxic doses of PUVA rejected tumors with a frequency similar to that seen in untreated animals, although these tumors grew progressively in UVB-irradiated mice. These results indicate that the effects of PUVA treatment differ from those of UVB irradiation in that PUVA treatment does not alter the immunologic rejection of UVB-induced tumors.
长期暴露于中波紫外线（UVB）辐射下在小鼠体内诱发的皮肤肿瘤通常具有高度抗原性，当移植到同基因正常动物体内时会消退，但在免疫抑制的小鼠体内会逐渐生长。将小鼠暴露于亚致癌剂量的UVB辐射下可消除这种免疫排斥现象。在本研究中，我们研究了8-甲氧基补骨脂素加紫外线A（UVA）辐射（PUVA）治疗对抗原性UVB诱导肿瘤排斥反应的影响。通过局部或全身给予补骨脂素进行PUVA治疗，并未改变UVB诱导肿瘤的正常排斥过程。用最小和明显光毒性剂量的PUVA治疗的小鼠排斥肿瘤的频率与未治疗动物相似，尽管这些肿瘤在UVB照射的小鼠体内会逐渐生长。这些结果表明，PUVA治疗的效果与UVB照射不同，因为PUVA治疗不会改变UVB诱导肿瘤的免疫排斥反应。
