Roberts L K, Schmitt M, Daynes R A
J Invest Dermatol. 1979 Jun;72(6):306-9. doi: 10.1111/1523-1747.ep12531746.
Evidence is presented to show that mice treated with various regimens of 8-methoxypsoralen followed by exposure to long-wave ultraviolet light (PUVA) are rendered tumor-susceptible when challenged with short-wave ultraviolet light (UVB) induced regressor tumors. These same tumors are readily rejected when implanted into normal syngeneic animals. Similar observations have been made in mice treated with subcarcinogenic doses of UVB, where it was shown that the tumor-susceptible state is mediated by suppressor T lymphocytes. These suppressor T-cells may be generated in response to antigens expressed by UVB damaged skin cells. It is now known that suppressor T-cells generated in mice treated with UVB are Ia-positive and have specificities for cross-reacting tumor antigens shared by all UVB-induced tumors, which have been tested to date. Our data suggest that, like UVB treated mice, treatment of mice with PUVA results in tumor-susceptibility mediated through the generation of Ia+ suppressor cells. Since PUVA treatments appear to generate a suppressor cell response in mice, a possible mechanism by which these treatments act to manage autoimmune type skin diseases, such as vitiligo, is discussed.
有证据表明，用各种8-甲氧基补骨脂素方案处理后再暴露于长波紫外线（PUVA）的小鼠，在受到短波紫外线（UVB）诱导的消退性肿瘤攻击时会变得易患肿瘤。而将这些相同的肿瘤植入正常同基因动物体内时，它们很容易被排斥。在用亚致癌剂量UVB处理的小鼠中也有类似的观察结果，结果表明肿瘤易患状态是由抑制性T淋巴细胞介导的。这些抑制性T细胞可能是对UVB损伤的皮肤细胞表达的抗原产生反应而产生的。现在已知，用UVB处理的小鼠中产生的抑制性T细胞是Ia阳性的，并且对迄今为止所测试的所有UVB诱导的肿瘤共有的交叉反应性肿瘤抗原有特异性。我们的数据表明，与UVB处理的小鼠一样，用PUVA处理小鼠会导致通过产生Ia +抑制细胞介导的肿瘤易感性。由于PUVA治疗似乎在小鼠中产生抑制细胞反应，因此讨论了这些治疗用于治疗自身免疫性皮肤病（如白癜风）的可能机制。
