Owen D A, Harvey C A, Quinn E H
Agents Actions. 1981 Apr;11(1-2):116-8. doi: 10.1007/BF01991477.
In vitro studies to analyse the pharmacology of histamine-induced dilatation of resistance vessels in rat hindquarters have been made. Histamine caused dose-dependent dilatation of resistance vessels over the concentration range 10(-9) to 10)-6) mol. Responses to histamine were antagonized by cimetidine but not my mepyramine. Dimaprit also caused vasodilatation. Responses to dimaprit were inhibited by cimetidine 10(-6) to 10(-5) M. A pA2 of 6.43 (6.11 - 6.75, 95% confidence limits) was calculated for cimetidine in the resistance vessels of the hindquarters.
已开展体外研究以分析组胺诱导大鼠后肢阻力血管扩张的药理学特性。在10(-9)至10(-6)摩尔的浓度范围内，组胺可引起阻力血管呈剂量依赖性扩张。西咪替丁可拮抗对组胺的反应，而甲氧苄二胺则无此作用。二甲双胍也可引起血管舒张。在10(-6)至10(-5)M浓度下，西咪替丁可抑制对二甲双胍的反应。计算得出西咪替丁在后肢阻力血管中的pA2为6.43（6.11 - 6.75，95%置信区间）。
