免疫复合物介导的复发性多软骨炎肾受累

Immune complex-mediated renal involvement in relapsing polychondritis.

作者信息

Espinoza L R, Richman A, Bocanegra T, Pina I, Vasey F B, Rifkin S I, Germain B F

出版信息

Am J Med. 1981 Jul;71(1):181-3. doi: 10.1016/0002-9343(81)90291-6.

Abstract

A patient with relapsing polychondritis who presented with rapidly progressive glomerulonephritis is described. This is the fourth case in which this association is reported. Crescentic glomerulonephritis was found on renal biopsy. Evidence for immunologic participation in the pathogenesis of this condition is suggested by the demonstration of circulating immune complexes, immunoglobulin and complement deposition by immunofluorescence, and electron dense deposits by electron microscopy of the kidney. Favorable response followed therapy with prednisone and dapsone.

摘要

本文描述了一名患有复发性多软骨炎并伴有快速进展性肾小球肾炎的患者。这是报道的第四例这种关联的病例。肾活检发现为新月体性肾小球肾炎。循环免疫复合物的检测、免疫荧光显示的免疫球蛋白和补体沉积以及肾脏电子显微镜检查发现的电子致密沉积物提示了免疫因素参与了该病的发病机制。泼尼松和氨苯砜治疗后反应良好。