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坏疽性脓皮病(溃疡性皮肤炎)和单克隆(IgA)球蛋白在美法仑治疗后痊愈。病例报告及文献综述。

Pyoderma gangraenosum (dermatitis ulcerosa) and monoclonal (IgA) globulin healed after melphalan treatment. Case report and review of the literature.

作者信息

Möller H, Waldenström J G, Zettervall O

出版信息

Acta Med Scand. 1978;203(4):293-6. doi: 10.1111/j.0954-6820.1978.tb14876.x.

DOI:10.1111/j.0954-6820.1978.tb14876.x
PMID:645442
Abstract

Since 1968 we have been treating a patient, who has had a combination of pyoderma gangraenosum (dermatitis ulcerosa) and signs that may indicate early multiple myeloma. She also had carcinoma of the colon, which was successfully operated. The pyoderma healed later after intensive and successful cytostatic treatment of the "myeloma". The ulcers remain practically healed and the protein pattern is normal in May 1977. Such cases are rare and a search in the literature has not been very rewarding. In our own series of more than 200 cases with myeloma this combination is unique. The lieterature is discussed in detail with data on the follow-up on some of the patients.

摘要

自1968年以来,我们一直在治疗一位患有坏疽性脓皮病(溃疡性皮肤病)且有早期多发性骨髓瘤迹象的患者。她还患有结肠癌,已成功接受手术。在对“骨髓瘤”进行强化且成功的细胞抑制治疗后,坏疽性脓皮病随后愈合。溃疡基本愈合,1977年5月蛋白质模式正常。此类病例罕见,查阅文献收获不大。在我们自己的200多例骨髓瘤病例系列中,这种组合是独一无二的。文中详细讨论了相关文献,并给出了部分患者的随访数据。

相似文献

1
Pyoderma gangraenosum (dermatitis ulcerosa) and monoclonal (IgA) globulin healed after melphalan treatment. Case report and review of the literature.坏疽性脓皮病(溃疡性皮肤炎)和单克隆(IgA)球蛋白在美法仑治疗后痊愈。病例报告及文献综述。
Acta Med Scand. 1978;203(4):293-6. doi: 10.1111/j.0954-6820.1978.tb14876.x.
2
Relapsing annular erythema and myeloma successfully treated with cyclophosphamide.环磷酰胺成功治疗复发性环状红斑和骨髓瘤。
Acta Med Scand. 1978;203(4):289-92. doi: 10.1111/j.0954-6820.1978.tb14875.x.
3
Pyoderma gangrenosum and monoclonal gammopathy.坏疽性脓皮病与单克隆丙种球蛋白病。
Arch Dermatol. 1983 Jun;119(6):468-72.
4
Clofazimine in dermatitis ulcerosa (pyoderma gangrenosum). Open clinical trial.氯法齐明治疗溃疡性皮肤病(坏疽性脓皮病)。开放性临床试验。
Dermatologica. 1988;177(4):232-6. doi: 10.1159/000248569.
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[Pyoderma gangrenosum, ovarian carcinoma treated with Melphalan and acute myelomonocytic leukaemia: report of one case and literature review (author's transl)].
Ann Dermatol Venereol. 1979 Mar;106(3):251-6.
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[Pyoderma gangrenosum with IgG-paraproteinemia in plasmacytoma].
Hautarzt. 1976 Dec;27(12):603-5.
7
[Gangrenous pyoderma and IgA-paraproteinemia].[坏疽性脓皮病与免疫球蛋白A副蛋白血症]
Z Hautkr. 1976 Feb 1;51(3):91-6.
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Pyoderma gangrenosum: successful treatment with minocycline.坏疽性脓皮病:米诺环素治疗成功案例
Clin Exp Dermatol. 1981 Mar;6(2):219-23. doi: 10.1111/j.1365-2230.1981.tb02294.x.
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[Ulcerative dermatitis (pyoderma gangrenosum) with selective IgA deficiency and development of an oral carcinoma].[伴有选择性IgA缺乏症及口腔癌发生的溃疡性皮肤病(坏疽性脓皮病)]
Z Hautkr. 1985 Jan;60(1-2):79-82.
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[Pyoderma gangraenosum and cardio-vasculopathies, particularly Takayasu arteritis. Review of the Japanese literature (author's transl)].
Ann Dermatol Venereol. 1981;108(1):13-21.

引用本文的文献

1
Postsurgical pyoderma gangrenosum after an autologous stem cell transplantation for multiple myeloma.多发性骨髓瘤自体干细胞移植术后发生坏疽性脓皮病。
BMJ Case Rep. 2018 Jan 5;2018:bcr-2017-222286. doi: 10.1136/bcr-2017-222286.
2
Multiple myeloma.多发性骨髓瘤
J R Coll Physicians Lond. 1979 Jul;13(3):146-53.