Illy N, Dalstein J M, Campo P, Loubatières-Mariani M M
C R Seances Soc Biol Fil. 1981;175(2):242-6.
Our experiments were carried out in normal and streptozotocin-diabetic rats. The effects of sodium difluoroacetate (DFA) at the dose of 40 mg/kg daily were studied on the blood and retinal lactate levels; these effects were compared to those of an identical dose of sodium dichloroacetate (DCA) which is the most known among the pyruvate dehydrogenase activators. DFA and DCA were administered orally by oesophageal tube during 5 months. At these doses, neither DFA nor DCA significantly modified the blood and retinal lactate levels in the normal animals. The blood and retina lactate levels of the non treated diabetic rats were much higher than those of the normal rats; the treatment by DFA and DCA significantly decreased the blood and retina lactate levels in diabetic rats.
我们的实验在正常大鼠和链脲佐菌素诱导的糖尿病大鼠中进行。研究了每日剂量为40mg/kg的二氟乙酸钠（DFA）对血液和视网膜乳酸水平的影响；并将这些影响与相同剂量的二氯乙酸钠（DCA）（丙酮酸脱氢酶激活剂中最知名的一种）的影响进行比较。通过食管管口服给予DFA和DCA，持续5个月。在这些剂量下，DFA和DCA均未显著改变正常动物的血液和视网膜乳酸水平。未治疗的糖尿病大鼠的血液和视网膜乳酸水平远高于正常大鼠；DFA和DCA治疗显著降低了糖尿病大鼠的血液和视网膜乳酸水平。
