Dalstein J M, Ribes G, Campo P, Loubatières-Mariani M M
C R Seances Soc Biol Fil. 1980;174(5):821-5.
In the anesthetized rat, the intraperitoneal injection of 40 mg/kg sodium difluoroacetate (DFA), an activator of the pyruvate dehydrogenase, counteracted the hyperlactatemia induced by a high dose of phenformin (40 mg/kg) injected concomitantly. In the normal conscious dog, the administration of 150 mg/kg by gastric intubation decreased the blood lactate and pyruvate levels; however, this effect was less marked than that produced by the same dose of sodium dichloroacetate (DCA).
在麻醉大鼠中，腹腔注射40mg/kg二氟乙酸钠（DFA，一种丙酮酸脱氢酶激活剂）可抵消同时注射高剂量苯乙双胍（40mg/kg）所诱导的高乳酸血症。在正常清醒犬中，经胃管给予150mg/kg可降低血液中乳酸和丙酮酸水平；然而，该效应不如相同剂量的二氯乙酸钠（DCA）所产生的效应明显。
