Lillehoj H S, Beisel K, Rose N R
J Immunol. 1981 Aug;127(2):654-9.
CDF (high responder) rats were crossed with SHR (low responder) rats to study genetic factors influencing susceptibility to experimental autoimmune thyroiditis (EAT). F1 hybrid rats showed intermediate susceptibility to thyroiditis. Gene segregation patterns of F2 and backcross rats demonstrated that the immune response to rat thyroglobulin (RaTg) is under polygenic control. A main factor controlling immune response to RaTg is associated with the X chromosome. Females of CDF and SHR rats produced higher levels of antibody, suggesting that antibody production to RaTg is a sex-influenced trait. Different genetic control mechanisms are evident in autoantibody production and thyroid lesions. No evidence of linkage of an immune response gene to RaTg to the major histocompatibility complex of the rat (RT1) was observed.
将C57BL/6J（高反应性）大鼠与SHR（低反应性）大鼠杂交，以研究影响实验性自身免疫性甲状腺炎（EAT）易感性的遗传因素。F1杂种大鼠对甲状腺炎表现出中等易感性。F2和回交大鼠的基因分离模式表明，对大鼠甲状腺球蛋白（RaTg）的免疫反应受多基因控制。控制对RaTg免疫反应的一个主要因素与X染色体有关。C57BL/6J和SHR大鼠的雌性产生更高水平的抗体，表明对RaTg的抗体产生是一种受性别影响的性状。自身抗体产生和甲状腺病变中存在不同的遗传控制机制。未观察到免疫反应基因与大鼠主要组织相容性复合体（RT1）的RaTg存在连锁的证据。
