自身免疫性甲状腺炎：环磷酰胺将低反应小鼠转化为高反应小鼠。
Autoimmune thyroiditis: conversion of low-responder mice to high-responders by cyclophosphamide.
作者信息
Vladutiu A O
出版信息
Clin Exp Immunol. 1982 Mar;47(3):683-8.
Abstract
Inbred strains of mice are low- or high-responders with respect to the magnitude of thyroid infiltrates that appear after immunization with mouse thyroglobulin emulsified in Freund's complete adjuvant. This aspect of the immune response to thyroglobulin is strongly controlled by the major histocompatibility complex. Low-responder strains treated with cyclophosphamide, before the antigenic challenge, were converted to high-responders. This suggests that in low-responder mice, a specific suppressor activity influences the development of the thyroid lesions characteristic for the autoimmune thyroiditis.
摘要
就用弗氏完全佐剂乳化的小鼠甲状腺球蛋白免疫后出现的甲状腺浸润程度而言，近交系小鼠有低反应者或高反应者之分。对甲状腺球蛋白的这种免疫反应方面受到主要组织相容性复合体的强烈控制。在抗原攻击前用环磷酰胺处理的低反应者品系转变为高反应者。这表明在低反应者小鼠中，一种特异性抑制活性影响自身免疫性甲状腺炎特征性甲状腺病变的发展。
相似文献
1
Autoimmune thyroiditis: conversion of low-responder mice to high-responders by cyclophosphamide.自身免疫性甲状腺炎：环磷酰胺将低反应小鼠转化为高反应小鼠。
Clin Exp Immunol. 1982 Mar;47(3):683-8.
2
Experimental autoimmune thyroiditis: modulation of the disease level in high and low responder mice by thymosin.实验性自身免疫性甲状腺炎：胸腺素对高反应性和低反应性小鼠疾病水平的调节
Clin Exp Immunol. 1984 Oct;58(1):83-9.
3
Autoimmune murine thyroiditis IX. Relationship of humoral and cellular immunity to thyroiditis in high and low responder mice.自身免疫性小鼠甲状腺炎IX. 高反应性和低反应性小鼠中体液免疫和细胞免疫与甲状腺炎的关系。
Eur J Immunol. 1977 Jan;7(1):40-3. doi: 10.1002/eji.1830070110.
4
5
Autoimmune murine thyroiditis. IV. Localization of genetic control of the immune response.自身免疫性小鼠甲状腺炎。IV. 免疫反应遗传控制的定位
J Immunol. 1974 Mar;112(3):965-9.
6
7
Thyroid function in mice with experimental autoimmune thyroiditis.实验性自身免疫性甲状腺炎小鼠的甲状腺功能
Clin Exp Immunol. 1985 Aug;61(2):257-64.
8
9
Autoimmune thyroiditis in young and old mice: differential effect of high doses of PHA.年轻和老年小鼠中的自身免疫性甲状腺炎：高剂量植物血凝素的不同作用
Immunology. 1982 Oct;47(2):233-8.
10
Spontaneous autoimmune thyroiditis in chickens. I. Effects of bursal reconstitution.鸡的自发性自身免疫性甲状腺炎。I. 法氏囊重建的影响。
J Immunol. 1981 Oct;127(4):1465-8.
引用本文的文献
1
2
Experimental autoimmune thyroiditis: modulation of the disease level in high and low responder mice by thymosin.实验性自身免疫性甲状腺炎：胸腺素对高反应性和低反应性小鼠疾病水平的调节
Clin Exp Immunol. 1984 Oct;58(1):83-9.
3
Genetic susceptibility to murine collagen II autoimmune arthritis. Proposed relationship to the IgG2 autoantibody subclass response, complement C5, major histocompatibility complex (MHC) and non-MHC loci.小鼠胶原II型自身免疫性关节炎的遗传易感性。与IgG2自身抗体亚类反应、补体C5、主要组织相容性复合体（MHC）和非MHC基因座的潜在关系。
J Exp Med. 1985 Dec 1;162(6):1878-91. doi: 10.1084/jem.162.6.1878.
4
Occurrence of lymphocyte proliferative response to thyroglobulin and antithyroglobulin antibodies in normal individuals: lack of correlation with HLA.正常个体中对甲状腺球蛋白和抗甲状腺球蛋白抗体的淋巴细胞增殖反应的发生：与人类白细胞抗原无相关性。
J Endocrinol Invest. 1987 Apr;10(2):203-6. doi: 10.1007/BF03347192.
本文引用的文献
1
2
T-cell regulation in autoimmune thyroiditis.自身免疫性甲状腺炎中的T细胞调节
Immunol Rev. 1981;55:299-314. doi: 10.1111/j.1600-065x.1981.tb00346.x.
3
Induction of experimental allergic encephalomyelitis in genetically resistant strains of mice.在基因抗性小鼠品系中诱导实验性变应性脑脊髓炎
Nature. 1980 Oct 9;287(5782):551-2. doi: 10.1038/287551a0.
4
Transfer of experimental autoimmune thyroiditis of the mouse by serum.通过血清转移小鼠实验性自身免疫性甲状腺炎
J Immunol. 1971 Apr;106(4):1139-42.
5
Suppression of thyroid lesions in rabbits by treatment with cyclophosphamide after the induction of thyroiditis.甲状腺炎诱导后用环磷酰胺治疗对兔甲状腺病变的抑制作用
Clin Exp Immunol. 1970 Oct;7(4):541-50.
6
Murine thyroiditis: importance of adjuvant and mouse strain for the induction of thyroid lesions.小鼠甲状腺炎：佐剂和小鼠品系在诱导甲状腺病变中的重要性。
J Immunol. 1971 Mar;106(3):698-704.
7
Murine thyroiditis. 3. Influence of syngeneic and allogeneic thyroid antigen on induction of the disease.小鼠甲状腺炎。3. 同基因和异基因甲状腺抗原对疾病诱导的影响。
Clin Exp Immunol. 1972 Jun;11(2):245-54.
8
Autoimmune murine thyroiditis. V. Genetic influence on the disease in BSVS and BRVR mice.自身免疫性小鼠甲状腺炎。V. BSVS和BRVR小鼠中疾病的遗传影响。
Clin Exp Immunol. 1973 Oct;15(2):281-7.
9
Peculiar immunobiology of bone marrow allografts. I. Graft rejection by irradiated responder mice.骨髓同种异体移植的特殊免疫生物学。I. 受照射的反应小鼠对移植物的排斥反应。
J Exp Med. 1971 Jul 1;134(1):83-102. doi: 10.1084/jem.134.1.83.
10
Transfer of experimental autoimmune thyroiditis by serum from thyroidectomized donors.来自甲状腺切除供体的血清对实验性自身免疫性甲状腺炎的转移。
J Exp Med. 1969 Aug 1;130(2):263-85. doi: 10.1084/jem.130.2.263.
Zotero 插件