Vladutiu A O
Clin Exp Immunol. 1982 Mar;47(3):683-8.
Inbred strains of mice are low- or high-responders with respect to the magnitude of thyroid infiltrates that appear after immunization with mouse thyroglobulin emulsified in Freund's complete adjuvant. This aspect of the immune response to thyroglobulin is strongly controlled by the major histocompatibility complex. Low-responder strains treated with cyclophosphamide, before the antigenic challenge, were converted to high-responders. This suggests that in low-responder mice, a specific suppressor activity influences the development of the thyroid lesions characteristic for the autoimmune thyroiditis.
就用弗氏完全佐剂乳化的小鼠甲状腺球蛋白免疫后出现的甲状腺浸润程度而言,近交系小鼠有低反应者或高反应者之分。对甲状腺球蛋白的这种免疫反应方面受到主要组织相容性复合体的强烈控制。在抗原攻击前用环磷酰胺处理的低反应者品系转变为高反应者。这表明在低反应者小鼠中,一种特异性抑制活性影响自身免疫性甲状腺炎特征性甲状腺病变的发展。