Schüpbach M E, de Serres F J
Mutat Res. 1981 Mar;81(1):49-58. doi: 10.1016/0027-5107(81)90086-5.
Gamma-Ray-induced inactivation and induction of mutations at the ad-3A and ad-3B loci of Neurospora crassa have been compared among 6 different UV-sensitive strains and a standard wild-type strain. The 6 strains show varying degrees of sensitivity to gamma-ray-induced inactivation, with the relative sensitivity at 37% survival being uvs-6 greater than upr-1 greater than uvs-2 greater than uvs-3 greater than wild-type greater than uvs-5 greater than uvs-4. Studies on the induction of ad-3 mutants by gamma-rays show that when the dose-response curve (expressed in terms of ad-3 mutants among the surviving colonies) of the UV-sensitive strains are compared with wild-type, the 2 excision-repair-deficient mutants uvs-2 and upr-1 exhibit enhanced ad-3 mutant frequencies, uvs-3 exhibits reduced ad-3 mutant frequencies whereas both uvs-4 and uvs-5 show lower mutant frequencies than wild-type.
在6种不同的对紫外线敏感的菌株和一个标准野生型菌株中，比较了γ射线诱导的粗糙脉孢菌ad - 3A和ad - 3B位点的失活和突变诱导情况。这6种菌株对γ射线诱导的失活表现出不同程度的敏感性，在37%存活时的相对敏感性为uvs - 6大于upr - 1大于uvs - 2大于uvs - 3大于野生型大于uvs - 5大于uvs - 4。关于γ射线诱导ad - 3突变体的研究表明，当将紫外线敏感菌株的剂量反应曲线（以存活菌落中的ad - 3突变体表示）与野生型进行比较时，两个切除修复缺陷突变体uvs - 2和upr - 1表现出增强的ad - 3突变频率，uvs - 3表现出降低的ad - 3突变频率，而uvs - 4和uvs - 5都显示出比野生型更低的突变频率。
