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粗糙脉孢菌单倍体紫外线敏感菌株中ad - 3A和ad - 3B位点的诱变。II. 紫外线诱导的失活和突变的剂量反应曲线比较。

Mutagenesis at the ad-3A and ad-3B loci in haploid UV-sensitive strains of Neurospora crassa. II. Comparison of dose-response curves for inactivation and mutation induced by UV.

作者信息

de Serres F J

出版信息

Mutat Res. 1980 Jul;71(2):181-91. doi: 10.1016/0027-5107(80)90069-x.

DOI:10.1016/0027-5107(80)90069-x
PMID:6446682
Abstract

UV-induced inactivation and induction of mutations at the ad-3A and ad-3B loci of Neurospora crassa have been compared among 7 different UV-sensitive strains and a standard wild-type strain. The 7 strains show varying degrees of sensitivity to UV-induced inactivation, with the relative sensitivity being: uvs-2 greater than uvs-3 greater than uvs-4 greater than uvs-6 greater than upr-1 greater uvs-5 greater than uvs-1. Studies on the induction of ad-3 mutants by UV show that the 2 excision-repair deficient mutants uvs-2 and upr-1 exhibit enhanced ad-3 mutant frequencies, while uvs-4 and uvs-5 exhibit reduced ad-3 mutant frequencies, and uvs-3 completely eliminates UV mutagenesis. The ad-3 mutation-induction curves obtained with uvs-1 or uvs-6 are not significantly different from that found with the wild-type strain.

摘要

在7种不同的对紫外线敏感的菌株和一个标准野生型菌株中，比较了紫外线诱导的粗糙脉孢菌ad - 3A和ad - 3B位点的失活和突变诱导情况。这7种菌株对紫外线诱导的失活表现出不同程度的敏感性，相对敏感性为：uvs - 2大于uvs - 3大于uvs - 4大于uvs - 6大于upr - 1大于uvs - 5大于uvs - 1。关于紫外线诱导ad - 3突变体的研究表明，2种切除修复缺陷型突变体uvs - 2和upr - 1表现出更高的ad - 3突变频率，而uvs - 4和uvs - 5表现出降低的ad - 3突变频率，uvs - 3则完全消除了紫外线诱变。用uvs - 1或uvs - 6获得的ad - 3突变诱导曲线与野生型菌株的曲线没有显著差异。

相似文献

1
Mutagenesis at the ad-3A and ad-3B loci in haploid UV-sensitive strains of Neurospora crassa. II. Comparison of dose-response curves for inactivation and mutation induced by UV.粗糙脉孢菌单倍体紫外线敏感菌株中ad - 3A和ad - 3B位点的诱变。II. 紫外线诱导的失活和突变的剂量反应曲线比较。
Mutat Res. 1980 Jul;71(2):181-91. doi: 10.1016/0027-5107(80)90069-x.
2
Mutagenesis at the ad-3A and ad-3B loci haploid UV-sensitive strains of Neurospora crassa. III. Comparison of dose-response curves for inactivation and mutation induced by gamma-rays.粗糙脉孢菌单倍体对紫外线敏感菌株在ad - 3A和ad - 3B位点的诱变。III. γ射线诱导的失活和突变剂量反应曲线的比较
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Mutagenesis at the ad-3A and ad-3B loci in haploid UV-sensitive strains of Neurospora crassa. V. Comparison of dose--response curves of single- and double-mutant strains with wild-type.粗糙脉孢菌单倍体紫外线敏感菌株中ad - 3A和ad - 3B位点的诱变。V. 单突变体和双突变体菌株与野生型的剂量反应曲线比较。
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5
Mutagenesis at the ad-3A and ad-3B loci in haploid UV-sensitive strains of Neurospora crassa. VI. Genetic characterization of ad-3 mutants provides evidence for qualitative differences in the spectrum of genetic alterations between wild-type and nucleotide excision-repair-deficient strains.粗糙脉孢菌单倍体紫外线敏感菌株中ad - 3A和ad - 3B位点的诱变。VI. ad - 3突变体的遗传特征为野生型和核苷酸切除修复缺陷型菌株之间遗传改变谱的定性差异提供了证据。
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6
Mutagenesis at the ad-3A and ad-3B loci in haploid UV-sensitive strains of Neurospora crassa. I. Development of isogenic strains and spontaneous mutability.粗糙脉孢菌单倍体紫外线敏感菌株中ad - 3A和ad - 3B位点的诱变。I. 同基因菌株的发育及自发突变率
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Ultraviolet-inactivation of conidia from heterokaryons of Neurospora crassa containing uv-sensitive mutations.含有紫外线敏感突变的粗糙脉孢菌异核体分生孢子的紫外线灭活
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Epistasis, photoreactivation and mutagen sensitivity of DNA repair mutants upr-1 and mus-26 in Neurospora crassa.粗糙脉孢菌中DNA修复突变体upr-1和mus-26的上位性、光复活作用及诱变敏感性
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Effect of the homokaryotic state of the uvs-2 allele in Neurospora crassa on formaldehyde-induced killing and ad-3 mutation.粗糙脉孢菌uvs - 2等位基因的同核状态对甲醛诱导杀伤和ad - 3突变的影响。
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Effect of the homokaryotic or heterokaryotic state of the uvs-2 allele in Neurospora crassa on mitomycin C-induced killing and ad-3 mutation.粗糙脉孢菌中uvs - 2等位基因的同核或异核状态对丝裂霉素C诱导杀伤及ad - 3突变的影响。
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引用本文的文献

1
Neurospora mutants sensitive both to mutagens and to histidine.对诱变剂和组氨酸都敏感的粗糙脉孢菌突变体。
Curr Genet. 1984 Dec;9(1):65-74. doi: 10.1007/BF00396206.
2
Deletion of a novel F-box protein, MUS-10, in Neurospora crassa leads to altered mitochondrial morphology, instability of mtDNA and senescence.在粗糙脉孢菌中缺失一个新的 F-box 蛋白 MUS-10 导致线粒体形态改变、mtDNA 不稳定和衰老。
Genetics. 2010 Aug;185(4):1257-69. doi: 10.1534/genetics.110.117200. Epub 2010 Jun 1.
3
Neurosprora crassa RAD5 homologue, mus-41, inactivation results in higher sensitivity to mutagens but has little effect on PCNA-ubiquitylation in response to UV-irradiation.
粗糙脉孢菌RAD5同源物mus-41的失活会导致对诱变剂的敏感性增加，但对紫外线照射后PCNA泛素化的影响很小。
Curr Genet. 2007 Sep;52(3-4):125-35. doi: 10.1007/s00294-007-0146-x. Epub 2007 Aug 17.
4
Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens.人类Rad18功能异常会导致复制后修复缺陷以及对多种诱变剂超敏。
Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):7927-32. doi: 10.1073/pnas.97.14.7927.
5
uvsI mutants defective in UV mutagenesis define a fourth epistatic group of uvs genes in Aspergillus.在紫外线诱变中存在缺陷的uvsI突变体确定了曲霉属中uvs基因的第四个上位性基因群。
Curr Genet. 1993 Jul-Aug;24(1-2):67-74. doi: 10.1007/BF00324667.
6
The Neurospora uvs-2 gene encodes a protein which has homology to yeast RAD18, with unique zinc finger motifs.粗糙脉孢菌uvs - 2基因编码一种与酵母RAD18具有同源性的蛋白质，带有独特的锌指基序。
Mol Gen Genet. 1993 Apr;238(1-2):225-33. doi: 10.1007/BF00279551.
7
Chromosomal loci of Neurospora crassa.粗糙脉孢菌的染色体位点。
Microbiol Rev. 1982 Dec;46(4):426-570. doi: 10.1128/mr.46.4.426-570.1982.
8
Chromosome instability in mutagen sensitive mutants of Neurospora.粗糙脉孢菌诱变敏感突变体中的染色体不稳定性
Curr Genet. 1986;10(5):381-7. doi: 10.1007/BF00418410.
9
Excision of pyrimidine dimers from the DNA of Neurospora.从粗糙脉孢菌DNA中切除嘧啶二聚体。
Mol Gen Genet. 1986 Feb;202(2):321-6. doi: 10.1007/BF00331658.
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Identification of DNA repair and damage induced proteins from Neurospora crassa.从粗糙脉孢菌中鉴定DNA修复和损伤诱导蛋白。
Mol Gen Genet. 1986 Jun;203(3):462-7. doi: 10.1007/BF00422071.