Navarra S, Melita P, Di Mauro S, Calbo L, Belnome N
Minerva Chir. 1981 Jun 30;36(12):853-60.
The hormone-dependence of breast cancer is recalled in a review of 448 metastasies cases observed between 1958 and 1978. It is shown that the percentage of positive response to hormone therapy is related to the type of treatment, menstrual age, metastasis site, and above all to the presence or absence of receptors for oestradiol, progesterone, and prolactin in the tumour tissue. The fact that hormone dependence can be evaluated via the search for such receptors means that projectine hormone management can be employed. This should lead to a marked improvement in the percentage of positive responses obtained in the treatment of metastasing breast carcinoma.
对1958年至1978年间观察到的448例乳腺癌转移病例的回顾中提到了乳腺癌的激素依赖性。结果表明，激素治疗的阳性反应百分比与治疗类型、月经年龄、转移部位有关，最重要的是与肿瘤组织中雌二醇、孕酮和催乳素受体的有无有关。通过寻找此类受体来评估激素依赖性这一事实意味着可以采用前瞻性激素管理。这应该会使转移性乳腺癌治疗中获得的阳性反应百分比显著提高。
