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[淋巴淤滞对肠吻合口愈合过程的影响。实验研究]

[Influence of lymphostasis on healing processes of intestinal anastomoses. Experimental research].

作者信息

De Franco S, Gabrielli M, Gelmetti M, Lampugnani R, Lagasi L, Sandona F, Zannoni M

出版信息

Acta Biomed Ateneo Parmense. 1981;52(1):95-103.

PMID:6455040
Abstract

The Authors studied the healing of the intestinal anastomoses in rats with mesenteric and celiac lymph-vessels coagulated and cut. The experiment was realized utilizing 104 rats, divided in fours groups: after the induction of the lymphostasis, in the first group an end-to-end ileal anastomosis was made by polyglycolic acid suture, 6/0 in diameter. The control groups consisted of rats with ileal anastomoses, with lymphostasis solely and sham operated. The macroscopic observation and the histological findings were studied 7 and 14 days after the anastomoses' performance. Only in the animals with lymphostasis was observed an anastomosal leakage of 19% at 7th day control. In the same period the histologic sections showed a modified anastomosal healing, related to the significant reduction of the granulomatous tissue formation in presence of the lymphostasis.

摘要

作者研究了肠系膜和腹腔淋巴管被凝固和切断的大鼠肠吻合口的愈合情况。该实验使用了104只大鼠,分为四组:在诱导淋巴停滞之后,第一组用直径为6/0的聚乙醇酸缝线进行端端回肠吻合。对照组由仅进行淋巴停滞处理的回肠吻合大鼠和假手术大鼠组成。在吻合术后7天和14天对宏观观察和组织学结果进行了研究。在第7天的对照中,仅在有淋巴停滞的动物中观察到19%的吻合口漏。在同一时期,组织学切片显示吻合口愈合有所改变,这与淋巴停滞时肉芽肿组织形成的显著减少有关。

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