淋巴淤滞对大鼠肠吻合口愈合的影响。

Effects of lymph stasis on healing of rat intestinal anastomosis.

作者信息

De Franco S, Gelmetti M, Lampugnani R, Gamrielli M

出版信息

Lymphology. 1984 Sep;17(3):100-4.

Abstract

The effects of lymphatic drainage on ileal anastomotic healing using interrupted polyglycolic acid sutures were studied in rats after division and obstruction of celiac-mesenteric lymphatics, and the data compared with sham-operated controls. In 4 of 20 rats with lymph stasis, but not sham-controls, anastomotic leakage was associated with generalized peritonitis and death. Histologic examination of the anastomotic site at 7 and 14 days revealed prolonged exudation with acute inflammatory reaction and less prominent granuloma formation where lymphatics were interrupted. Whereas foreign body giant cell reaction predominated at 14 days with lymph stasis, histiocytic and fibroblastic proliferation dominated in sham-controls. The data suggest that an intact lymphatic system favors optimal intestinal healing and repair.

摘要

在大鼠腹腔 - 肠系膜淋巴管被切断和阻塞后，研究了使用间断聚乙醇酸缝线进行淋巴引流对回肠吻合口愈合的影响，并将数据与假手术对照组进行比较。在20只存在淋巴淤滞的大鼠中，有4只出现吻合口漏，伴有弥漫性腹膜炎和死亡，而假手术对照组未出现这种情况。在第7天和第14天对吻合口部位进行组织学检查发现，在淋巴管被中断的部位，渗出延长，伴有急性炎症反应，肉芽肿形成不明显。在淋巴淤滞的情况下，14天时以异物巨细胞反应为主，而在假手术对照组中，组织细胞和成纤维细胞增殖占主导。数据表明，完整的淋巴系统有利于肠道的最佳愈合和修复。