前列腺素对大鼠心肌肌原纤维ATP酶活性无影响。

Lack of effect of prostaglandins on rat heart myofibrillar ATPase activity.

作者信息

Pierce G N, Karmazyn M, Daly M J, Dhalla N S

出版信息

Prostaglandins Med. 1981 Jun;6(6):633-9. doi: 10.1016/0161-4630(81)90125-7.

Abstract

Although various prostaglandins have been shown to elicit an inotropic response in the rat heart, the subcellular basis responsible for this effect is unknown. The purpose of this study was to examine the influence of three prostaglandins with varying inotropic potencies on myofibrillar ATPase activity in the rat heart. PGF2 alpha, PGI2 and PGE2 were found to have no influence on basal or Ca2+-stimulated myofibrillar ATPase activity. In addition, no influence was observed on the sensitivity of myofibrillar ATPase activity to Ca2+. Alternative mechanisms to explain the inotropic effect are discussed.

摘要

尽管已表明多种前列腺素可引起大鼠心脏的变力反应，但负责这种效应的亚细胞基础尚不清楚。本研究的目的是检查三种具有不同变力效力的前列腺素对大鼠心脏肌原纤维ATP酶活性的影响。发现PGF2α、PGI2和PGE2对基础或Ca2+刺激的肌原纤维ATP酶活性没有影响。此外，未观察到对肌原纤维ATP酶活性对Ca2+敏感性的影响。讨论了解释变力作用的其他机制。