Dellon A L, Curtis R M, Cooley B C
Ann Plast Surg. 1981 Jul;7(1):38-43. doi: 10.1097/00000637-198107000-00006.
Intravascular coagulation is the final common pathway of failure in replanted digits and "free" tissue transfers. To address this clinical problem, a model based upon intimal damage and stasis in the rat femoral vein was developed. The ability of local, intraarterially administered Thrombolysin to achieve "local" clot lysis was investigated. "Systemic anticoagulation" was measured by standard hematologic monitoring and "systemic thrombolysis" by lysis of a contralateral standard femoral vein clot. The mean drug volume required for local clot lysis was proportional to the clots' duration time; 7.8 ml required for the 30-minute, and 17.0 ml required for the 60-minute clot (p less than 0.05). Lysis was achieved by local intraarterial Thrombolysin in 87% of the clots of 30 minutes' duration and in 94% of the clots of 60 minutes' duration. Overall, just 3.6% of contralateral clots lysed (p less than 0.001). Systemic anticoagulation did not occur.
血管内凝血是再植手指和“游离”组织移植失败的最终共同途径。为了解决这一临床问题，建立了一种基于大鼠股静脉内膜损伤和血流淤滞的模型。研究了经动脉局部给药溶栓素实现“局部”血栓溶解的能力。通过标准血液学监测测定“全身抗凝”情况，通过对侧标准股静脉血栓溶解测定“全身溶栓”情况。局部血栓溶解所需的平均药物体积与血栓持续时间成正比；30分钟血栓需要7.8毫升，60分钟血栓需要17.0毫升（p小于0.05）。在持续30分钟的血栓中，87%通过局部动脉内溶栓素实现溶解，在持续60分钟的血栓中，94%实现溶解。总体而言，对侧血栓仅有3.6%溶解（p小于0.001）。未发生全身抗凝。
