Edwards W D, Edwards J E
Am J Cardiol. 1978 May 1;41(5):921-4. doi: 10.1016/0002-9149(78)90734-8.
In subjects with classic complete transposition (d-transposition) of the great arteries, the pulmonary arterial plexiform lesion, characteristic of chronic high levels of pulmonary arterial pressure, was observed in those with an intact ventricular septum as well as in those with a ventricular septal defect. The lesion was not observed before age 12 months. Among 16 patients aged 12 to 30 months, the plexiform lesion was observed in 6 of 12 patients (50 percent) with an intact ventricular septum and a closed ductus arteriosus and in 1 of 4 patinets with an associated ventricular septal defect. The basis of the plexiform lesion, which is considered a sign of chronic severe pulmonary hypertension, occurring in subjects with an intact ventricular septum and a closed ductus arteriosus is not explained. The phenomenon observed in this study confirms the earlier observations of others.
在患有经典型完全性大动脉转位（d-转位）的受试者中，在室间隔完整者以及伴有室间隔缺损者中均观察到了肺动脉丛状病变，这是慢性肺动脉高压的特征性表现。该病变在12个月龄之前未被观察到。在16例年龄在12至30个月的患者中，在12例室间隔完整且动脉导管未闭的患者中有6例（50%）观察到了丛状病变，在4例伴有室间隔缺损的患者中有1例观察到了该病变。对于在室间隔完整且动脉导管未闭的受试者中出现的被认为是慢性重度肺动脉高压标志的丛状病变的基础，目前尚无解释。本研究中观察到的现象证实了其他人早期的观察结果。
