T细胞发育。辅助效应细胞集和反馈抑制诱导细胞集的前体及诱导剂需求。
T cell development. Precursors and inducer requirements of helper effector and feedback suppression inducer cell sets.
作者信息
Shen F W, McDougal J S, Bard J, Cort S P
出版信息
J Exp Med. 1981 Sep 1;154(3):935-41. doi: 10.1084/jem.154.3.935.
The surface phenotypes and differentiative history of specific helper-effector (HE) and specific feedback suppression-inducer (FBSI) cell sets were further defined in reference to the Qa-1 and I-J marker systems by culture of selected sets of cortisone-resistant nylon-purified thymocytes with antigen on primed macrophages. The generation of Ly-1:HE and Ly-1:FBSI cell sets required, in each case, two initiating sets: a precursor set and a differentiation-inducing set. Precursor sets were distinguished from inducer sets by genetic markers. Accordingly, HE cells, phenotype Ly-1:Qa-1-:I-J-, differentiated from Ly-123:Qa-1- cells in the presence of Ly-1:Qa-1+:I-J+ inducer cells; and FBSI cells, phenotype Ly-1:Qa-1+:I-J+, differentiated from Ly-123:Qa-1- in the presence of Ly-1:Qa-1+:I-J+ inducer cells. The Ly-123:Qa-1-precursors of HE and FBSI cells have been distinguished from one another previously but there is as yet no evidence whether differentiation of these precursor sets requires the same or different Ly-1:Qa-1+:I-J+ inducer sets.
通过用抗原刺激的巨噬细胞培养选定的耐可的松尼龙纯化胸腺细胞集，参照Qa-1和I-J标记系统，进一步确定了特定辅助效应细胞（HE）和特定反馈抑制诱导细胞（FBSI）集的表面表型和分化历史。Ly-1:HE和Ly-1:FBSI细胞集的产生在每种情况下都需要两个起始集：一个前体细胞集和一个分化诱导细胞集。前体细胞集通过遗传标记与诱导细胞集区分开来。因此，表型为Ly-1:Qa-1-:I-J-的HE细胞在Ly-1:Qa-1+:I-J+诱导细胞存在的情况下从Ly-123:Qa-1-细胞分化而来；表型为Ly-1:Qa-1+:I-J+的FBSI细胞在Ly-1:Qa-1+:I-J+诱导细胞存在的情况下从Ly-123:Qa-1-细胞分化而来。HE和FBSI细胞的Ly-123:Qa-1-前体细胞此前已相互区分，但尚无证据表明这些前体细胞集的分化需要相同或不同的Ly-1:Qa-1+:I-J+诱导细胞集。
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