De los Cobos L, Ligia A P
J Genet Hum. 1981 Feb;28(5):201-6.
A chromosome 21p- was observed in double dose in a trisomic 21 patient; the mother and other members of her family, in three generations, were carriers of this marker chromosome. After the analysis of similar families reported in the literature, the possible role of this marker in non disjunction and its segregation during meiosis is discussed.
在一名21三体患者中观察到双倍剂量的21号染色体短臂缺失；其母亲及家族中的其他三代成员均为这条标记染色体的携带者。在分析了文献中报道的类似家族后，讨论了该标记在减数分裂过程中不分离及其分离中的可能作用。
