Elwood J H, Darragh P M
J Ment Defic Res. 1981 Sep;25(Pt 3):157-60. doi: 10.1111/j.1365-2788.1981.tb00105.x.
An estimate of prevalence of mongolism at birth in Northern Ireland (1960-69 gave a frequency of 2.23 per 1000 livebirths. This figure is considerably higher than from other published sources within the United Kingdom. The estimate was derived by applying mortality experience of a sample of mongols over a recent time period. Mortality among mongols born to older mothers was after one year almost fifty per cent whilst those born to younger mothers was twenty-three per cent. These findings have implications for the viability of future screening programmes.
北爱尔兰1960年至1969年出生时唐氏综合征的患病率估计为每1000例活产中有2.23例。这一数字远高于联合王国内其他已发表资料中的数据。该估计是通过应用近期一段时间内唐氏综合征患者样本的死亡率经验得出的。高龄母亲所生唐氏综合征患儿一岁后的死亡率约为50%,而低龄母亲所生患儿的死亡率为23%。这些发现对未来筛查项目的可行性具有启示意义。