[阴离子对线粒体氧化磷酸化及ATP酶活性的影响]
[Effect of anions on the oxidative phosphorylation and ATPase activity in mitochondria].
作者信息
Ivashchenko A T, Kozhanova S V
出版信息
Vopr Med Khim. 1981 May-Jun;27(3):313-7.
PMID:6456596
Abstract
Bicarbonate, sulfate and thiocyanate affected distinctly the ADP/O ratio and the rate of oxygen consumption in liver mitochondria. Alterations in the ADP/O coefficient and the ATPase activity were studied in liver and heart mitochondria of control and fasted rats as well as of animals maintained under hypoxy-hypercapnic conditions. Satisfactory correlation was shown between a decrease both in the ADP/O ratio and in sensitivity of ATPase to bicarbonate in liver mitochondria of the animals subjected to these treatments.
摘要
碳酸氢盐、硫酸盐和硫氰酸盐对肝线粒体中的ADP/O比值和氧消耗速率有明显影响。在对照大鼠、禁食大鼠以及处于低氧高碳酸血症条件下饲养的动物的肝脏和心脏线粒体中，研究了ADP/O系数和ATP酶活性的变化。在接受这些处理的动物的肝线粒体中，ADP/O比值的降低与ATP酶对碳酸氢盐敏感性的降低之间呈现出良好的相关性。
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