Ogata M, Hasegawa T, Yamazaki Y, Nogami Y
Acta Med Okayama. 1978 Dec;32(6):387-92.
The effect of Cd2+ on the respiration of rat liver mitochondria was investigated. The uncoupling effect of Cd2+ was partially restored by the addition of Mg2+. The influence of Cd2+ on adenine nucleotide concentrations in the reaction mixture consisting of mitochondria and ATP was also studied using high performance liquid chromatography. In the presence of added Mg2+, a two-fold increase in AMP concentration was brought about by the addition of Cd2+. There was a concomitant decrease in ATP. In the prence of added ADP, an increase in AMP concentration was also brought about by addition of Cd2+. The results are discussed in relation to ATPase and adenylate kinase activity in mitochondria.
研究了Cd2+对大鼠肝脏线粒体呼吸的影响。添加Mg2+可部分恢复Cd2+的解偶联作用。还使用高效液相色谱法研究了Cd2+对由线粒体和ATP组成的反应混合物中腺嘌呤核苷酸浓度的影响。在添加Mg2+的情况下，添加Cd2+会使AMP浓度增加两倍。同时ATP减少。在添加ADP的情况下，添加Cd2+也会使AMP浓度增加。结合线粒体中的ATP酶和腺苷酸激酶活性对结果进行了讨论。
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