Ursin R
Waking Sleeping. 1980 Jul-Sep;4(3):211-21.
Sleep-waking stages and PGO activity were continuously recorded for 2 days following a control injection and for 5 days following a single injection of 200 mg/kg PCPA. Following PCPA, quiet waking with desynchronized EEG activity (W-1 quiet) was increased, while waking with synchronous EEG activity (W-2) was reduced dramatically. Active waking (W-1 active) was not changed. Sleep was reduced following PCPA, in particular slow wave sleep with slow synchronous waves (SWS-2). The distribution of PGO activity on the sleep-waking stages was altered after PCPA. The sleep-waking changes preceded the PGO wave redistribution by 12--18 hours. The data do not support the PGO wave activation hypothesis for the sleep loss following PCPA administration. It is concluded that PCPA affects a deactivating, possibly slow wave producing mechanism, affecting relaxed waking and deep slow wave sleep but not sleep per se.
在进行对照注射后的2天以及单次注射200mg/kg对氯苯丙氨酸（PCPA）后的5天内，持续记录睡眠-觉醒阶段和脑桥-膝状体-枕叶（PGO）活动。注射PCPA后，脑电图活动去同步化的安静觉醒（W-1安静）增加，而脑电图活动同步化的觉醒（W-2）显著减少。主动觉醒（W-1主动）未改变。注射PCPA后睡眠减少，尤其是伴有慢同步波的慢波睡眠（SWS-2）。PCPA后，PGO活动在睡眠-觉醒阶段的分布发生改变。睡眠-觉醒变化比PGO波重新分布提前12 - 18小时。这些数据不支持PCPA给药后睡眠丧失的PGO波激活假说。得出的结论是，PCPA影响一种失活机制，可能是产生慢波的机制，影响放松觉醒和深度慢波睡眠，但不影响睡眠本身。
