McKenzie M W, Beck D C, Popovich N G
Arch Dermatol. 1981 Oct;117(10):630-4.
This study evaluated the effectiveness of topically applied clindamycin hydrochloride and clindamycin phosphate in two, nonprescription, antiacne hydroalcoholic products for the treatment of acne vulgaris. Two percent concentrations of these clindamycin compounds were compared with the hydroalcoholic products in patients with moderate to severe acne who were attending a private dermatology office practice during a three-month period. Statistical analysis revealed a significantly greater clinical effectiveness for the clindamycin formulations compared with the hydroalcoholic products after eight weeks. The effectiveness of clindamycin compared with the hydroalcoholic products was not significantly greater after four and 12 weeks. The following are the possible reasons for this nonsignificant difference: a placebo effect within the first month, relative ineffectiveness of one type of clindamycin formulation tested, and the impressive clinical effectiveness of the antiacne hydroalcoholic products when combined with a consistent cleansing program.
本研究评估了两种非处方抗痤疮水醇性产品中局部应用的盐酸克林霉素和磷酸克林霉素治疗寻常痤疮的有效性。在三个月的时间里，将这些克林霉素化合物的2%浓度与水醇性产品在中度至重度痤疮患者中进行比较，这些患者在一家私立皮肤科诊所就诊。统计分析显示，八周后，与水醇性产品相比，克林霉素制剂的临床有效性显著更高。在四周和十二周后，克林霉素与水醇性产品相比，有效性没有显著更高。造成这种无显著差异的可能原因如下：第一个月内的安慰剂效应、所测试的一种克林霉素制剂相对无效，以及抗痤疮水醇性产品与持续清洁方案联合使用时令人印象深刻的临床有效性。
