Rozonov Iu B
Farmakol Toksikol. 1981 Jul-Aug;44(4):410-4.
Experiments on unanesthetized cats (conscious and curarized) were made to analyze the method of studying the effect of pharmacological substances on the pressor vasomotor reflexes produced by nociceptive stimulation. It was shown that the activity profiles of the drugs depend not only on their cardiovascular properties but also on the parameters of stimulation applied to the reflex recording, which is related to the shape of the curve of reflex magnitude dependence on the stimulation intensity. The most precise test in the application of the method to the unanesthetized animals involved the recording of the threshold of reflex occurrence, with the use of curare-like drugs being mandatory. Making of experiments without use of the curare-like agents or without considering the shape of the curve of reflex magnitude dependence on the parameters of stimulation might lead to errors in the appraisal of the results obtained.
对未麻醉的猫（清醒和箭毒化的）进行了实验，以分析研究药理物质对伤害性刺激产生的升压血管运动反射作用的方法。结果表明，药物的活性谱不仅取决于其心血管特性，还取决于应用于反射记录的刺激参数，这与反射幅度对刺激强度的依赖曲线形状有关。将该方法应用于未麻醉动物时，最精确的测试涉及记录反射发生的阈值，必须使用箭毒样药物。不使用箭毒样药物或不考虑反射幅度对刺激参数的依赖曲线形状进行实验，可能会导致对所得结果评估的错误。
