[Thio-tepa treatment for prevention of recurrence of surgically treated bladder tumors].

A total of 12 patients were prophylactically treated with Thio-Tepa, that had presented papillary bladder tumours operated in stages T0, T1 and T2. The treatment consisted in intra-vesical instillations with 50 mg of substance solved in 50 ml of distilled water. The solution was maintained for one hour inside the urinary bladder. The instillations were repeated at 5--7 days intervals for 4 times. The following series of instillations was carried out at 3--4 months intervals by comparing the results with those obtained in a control lot it was noted that 41 percent of the patient did not recidivate over a period of between 13 and 34 months, while recidives, occurred in all the patients in the control lot. On the other hand intra-vesical instillations with Thio-Tepa have retarded in some of the cases the occurrence of tumoral recidives (22 percent of the patients recidivated in the first 6 months, in contrast with the controls in whom recidives occurred in 72 percent in the same time interval). No secondary effects were noted as a result of the endo-vesical instillations with the preparation.