Cardan E, Hârsovescu G, Petrilă T, Tulbure D, Litarczek G
Rev Chir Oncol Radiol O R L Oftalmol Stomatol Chir. 1980 Jul-Aug;29(4):309-14.
The antagonising effect induced on respiratory depression by fentanyl and morphine was studied in two lots of patients. Recovery from respiratory depression was general and evident. A correlation was found between the amount of naloxone and the amount of the major analgesic used. Beside respiratory depression naloxone has also partially antagonised in some cases the analgesic effects of fentanyl and morphine.
在两组患者中研究了纳洛酮对芬太尼和吗啡所致呼吸抑制的拮抗作用。呼吸抑制的恢复普遍且明显。发现纳洛酮的用量与主要镇痛药的用量之间存在相关性。除呼吸抑制外，纳洛酮在某些情况下还部分拮抗了芬太尼和吗啡的镇痛作用。
