Schaer H, Baasch K
Anaesthesist. 1978 Nov;27(11):538-9.
The respiratory depressant effect of tilidine (valoron) was investigated in anaesthetized patients. One hundred mg of tilidine had a slight respiratory depressant effect which was without importance in awake subjects. The respiratory depression caused by tilidine could be antagonized by naloxone while the analgesic effect was maintained. This suggests a dissociation of the mechanisms responsible for the respiratory and the analgesic actions.
在麻醉患者中研究了替利定（瓦洛隆）的呼吸抑制作用。100毫克替利定具有轻微的呼吸抑制作用，这在清醒受试者中并不重要。替利定引起的呼吸抑制可被纳洛酮拮抗，同时镇痛作用得以维持。这表明负责呼吸和镇痛作用的机制是分离的。
