Kimberly R P, Bowden R E, Keiser H R, Plotz P H
Am J Med. 1978 May;64(5):804-7. doi: 10.1016/0002-9343(78)90520-x.
Because aspirin and indomethacin, two structurally dissimilar anti-inflammatory agents which reduce prostaglandin synthesis, both alter renal function, we studied the effect on renal function of three new nonsteroidal anti-inflammatory drugs which also reduce prostaglandin synthesis. We have shown that ibuprofen, naproxen, and fenoprofen are able to reduce renal function in patients with systemic lupus erythematosus and that such changes are associated with reduced excretion of urinary prostaglandin E (PGE)-like compounds. The changes may attenuate despite continued drug administration. These findings emphasize that renal function must be assessed with caution in patients taking these and perhaps other drugs which inhibit prostaglandin synthesis.
由于阿司匹林和消炎痛这两种结构不同但能减少前列腺素合成的抗炎药都会改变肾功能，因此我们研究了另外三种同样能减少前列腺素合成的新型非甾体抗炎药对肾功能的影响。我们已经表明，布洛芬、萘普生和非诺洛芬能够降低系统性红斑狼疮患者的肾功能，而且这些变化与尿中前列腺素E（PGE）样化合物排泄减少有关。尽管持续用药，这些变化可能会减弱。这些发现强调，对于服用这些以及可能其他抑制前列腺素合成药物的患者，必须谨慎评估其肾功能。
