Rasmussen S, Petersen J, Nielsen I L, Christensen P, Hilden T
Eur J Clin Pharmacol. 1982;23(6):505-8. doi: 10.1007/BF00637497.
Glomerular filtration rate (GFR; 51Cr-EDTA clearance), serum creatinine concentration and urinary excretion of prostaglandins were measured in 8 patients with systemic lupus erythematosus (SLE) before and after 2 weeks of treatment with acetylsalicylic acid (ASA). ASA 65 mg/kg or up to 4 g/daily was given as a sustained release preparation. The serum salicylate concentration ranged from 0.3 to 1.6 mmol/l. Serum creatinine after 1 and 2 weeks and GFR after 2 weeks of ASA treatment showed no significant changes. There was a clearcut decrease in urinary excretion of prostaglandins PGE2 and PGF2 alpha, by 44% and 50%, respectively. It is concluded that therapeutic doses of ASA do not cause deterioration of GFR in patients with SLE and normal or moderately reduced renal function.
对8例系统性红斑狼疮（SLE）患者在服用乙酰水杨酸（ASA）治疗2周前后，测定了肾小球滤过率（GFR；51铬-乙二胺四乙酸清除率）、血清肌酐浓度和前列腺素的尿排泄量。以缓释制剂形式给予ASA 65mg/kg或每日最高4g。血清水杨酸盐浓度范围为0.3至1.6mmol/L。ASA治疗1周和2周后的血清肌酐以及治疗2周后的GFR均无显著变化。前列腺素PGE2和PGF2α的尿排泄量明显减少，分别减少了44%和50%。得出的结论是，治疗剂量的ASA不会导致肾功能正常或中度降低的SLE患者的GFR恶化。
