de Angelis G L, Gregori G, Bini F, Zanacca C, Soliani U, Minopoli M R, Banchini G
Acta Biomed Ateneo Parmense. 1981;52(2-3):165-73.
In this study we report our experience with 50 intestinal biopsies carried out in 35 children in a 14 months period (October 1979-December 1980) and we also describe the technique we use. The biopsy has been performed by two operators using the Crosby capsule, placed at the duodenojejunal flexure under fluoroscopic screening. For sedation we used oral Promazine and viscous xylocaine and i.v. Metoclopramide and Diazepam; the sedation has been classified in 4 degrees and resulted very good in 40 cases, good in 8 cases and sufficient in 2. The biopsy specimens has been examined with dissecting and light microscope and demonstrated 14 sub-total villous atrophy, 2 severe partial villous atrophy, 5 partial villous atrophy and 29 normal villous morphology. By this technique we made a diagnosis of Coeliac disease in 8 cases, suspected Coeliac disease in 3 cases, Dermatitis Herpetiformis in 3 cases and cow's milk proteins intolerance and post-enteritis syndrome in 1 case. No complications occurred during or after intubation. The AA. confirm the diagnostic value of this investigation, its safety and its very high degree of sensitivity superior to any other test of intestinal absorption.
在本研究中，我们报告了在14个月期间（1979年10月至1980年12月）对35名儿童进行50次肠道活检的经验，并描述了我们所使用的技术。活检由两名操作人员使用克罗斯比胶囊进行，在荧光透视下置于十二指肠空肠曲处。镇静方面，我们使用了口服异丙嗪和粘性利多卡因以及静脉注射甲氧氯普胺和地西泮；镇静程度分为4级，40例效果非常好，8例良好，2例足够。活检标本经解剖显微镜和光学显微镜检查，显示14例全绒毛萎缩、2例严重部分绒毛萎缩、5例部分绒毛萎缩和29例正常绒毛形态。通过该技术，我们诊断出8例乳糜泻、3例疑似乳糜泻、3例疱疹样皮炎以及1例牛奶蛋白不耐受和肠炎后综合征。插管期间及之后均未发生并发症。作者证实了该项检查的诊断价值、安全性及其极高的敏感性，优于任何其他肠道吸收试验。
