Balli F, Giberti G, Bertolani P, Amarri S, Palmieri R, Olivi O
Pediatr Med Chir. 1986 Sep-Oct;8(5):611-4.
Cow's milk sensitive enteropathy has been described several times but in spite of that, it is still a problem concerning the pathogenesis. Our study involves the children hospitalized from 1974 to 1984 in the First Department of Pediatrics, University of Modena. Patients were suffering from chronic diarrhea and malabsorption. At the first biopsy each child showed atrophy of the small intestinal mucosa. All patients had been fed fed with gluten. We have followed the protocol for Celiac Disease's diagnosis; we found proved 85% of cases, excluded 15%. These last cases may be considered as cow's milk sensitive enteropathy. We catamnestically considered all the clinical and laboratory data of the two groups in the purpose of selecting significative parameters for a differential diagnosis. The data meaning fully different between the two groups resulted: family history of allergy, recurrent infections, positive occult blood in the stools, eosinophils in blood greater than 400/mm3 serum IgE value greater than 97 degrees P X (p less than 0.01). On the ground of recent studies the involvement of the cell-mediated immunity in cow's milk sensitive enteropathy is supposed.
牛乳敏感肠病已被多次描述，但尽管如此，其发病机制仍是个问题。我们的研究涉及1974年至1984年在摩德纳大学第一儿科住院的儿童。这些患者患有慢性腹泻和吸收不良。在首次活检时，每个儿童均显示小肠黏膜萎缩。所有患者均曾食用含麸质食物。我们遵循了乳糜泻的诊断方案；我们确诊了85%的病例，排除了15%。最后这些病例可被视为牛乳敏感肠病。我们对两组的所有临床和实验室数据进行随访观察，以便选择有鉴别诊断意义的参数。两组之间存在显著差异的数据结果如下：过敏家族史、反复感染、粪便潜血阳性、血液中嗜酸性粒细胞大于400/mm³、血清IgE值大于97单位（p小于0.01）。基于最近的研究，推测细胞介导免疫参与了牛乳敏感肠病的发病过程。
