Czernicki J, Tchórzewski H, Lewicki R, Orzel H
Arch Immunol Ther Exp (Warsz). 1981;29(3):355-60.
Lysosome proteins derived from peripheral blood granulocytes of patients with multiple sclerosis (MS), lupus erythematosus (LE), rheumatoid arthritis (RA) and recurrent uveitis cause the impairment of Con A-induced suppressor cell activity in two-step culture in vitro. This effect is independent of lysosome protease activity. Such a phenomenon, observed in vitro, may cause disturbances in suppressor cell function in the course of the above diseases.
来自多发性硬化症（MS）、红斑狼疮（LE）、类风湿性关节炎（RA）和复发性葡萄膜炎患者外周血粒细胞的溶酶体蛋白，在体外两步培养中会导致刀豆球蛋白A诱导的抑制细胞活性受损。这种效应与溶酶体蛋白酶活性无关。在体外观察到的这种现象，可能会在上述疾病过程中引起抑制细胞功能紊乱。
