Dreslinski G R, Messerli F H, Dunn F G, Suarez D H, Frohlich E D
Chest. 1981 Nov;80(5):592-5. doi: 10.1378/chest.80.5.592.
To assess patterns of left ventricular adaptation, 38 patients with borderline and 38 with sustained mild essential hypertension, all lacking electrocardiographic and roentgenographic criteria for left ventricular hypertrophy, were compared using systemic hemodynamic values and M-mode echocardiograms. All patients had normal left ventricular function and measurements of wall thickness. Those with borderline hypertension showed no asymmetric increase in the ratio of septal to posterior wall thickness. The ratio of the left ventricular radius to wall thickness remained normal in both groups, indicating no disproportionate hypertrophy or dilatation of chambers during the phase of normal left ventricular function. Neither finding substantiates asymmetric septal hypertrophy in early hypertension. Those with mild essential hypertension demonstrated an augmented mean circumferential fiber shortening rate compared to those with borderline hypertension (P less than 0.005), suggesting an early stage of left ventricular hyperfunction in the development and elaboration of hypertensive heart disease.
为评估左心室适应性模式，对38例临界高血压患者和38例持续性轻度原发性高血压患者进行了比较，所有患者均无心电图和X线片左心室肥厚标准，采用系统血流动力学值和M型超声心动图进行评估。所有患者左心室功能和室壁厚度测量均正常。临界高血压患者室间隔与后壁厚度比值未出现不对称增加。两组左心室半径与室壁厚度比值均保持正常，表明在左心室功能正常阶段，心室无不成比例的肥厚或扩张。这两项发现均不能证实早期高血压存在不对称性室间隔肥厚。与临界高血压患者相比，轻度原发性高血压患者平均圆周纤维缩短率增加（P<0.005），提示在高血压性心脏病发生和发展过程中左心室功能亢进处于早期阶段。
