亨廷顿舞蹈病患者大脑中神经元特异性烯醇化酶和非神经元烯醇化酶的水平

Brain levels of neuron-specific and nonneuronal enolase in Huntington's disease.

作者信息

Marangos P J, Paul S M

出版信息

J Neurochem. 1981 Nov;37(5):1338-40. doi: 10.1111/j.1471-4159.1981.tb04687.x.

DOI:10.1111/j.1471-4159.1981.tb04687.x

Abstract

Levels of the cell-specific brain isoenzymes of enolase were determined in basal ganglia and cerebral cortical tissue of Huntington's disease and age- and sex-matched control brain. Neuron-specific enolase (NSE) levels are decreased an average of 45% in basal ganglia from patients with Huntington's disease whereas the glial-specific form of enolase, nonneuronal enolase (NNE), is not significantly altered. In contrast, levels of NSE in cerebral cortical tissue from Huntington's disease patients remains unchanged in comparison with controls whereas NNE levels are significantly increased. NNE and NSE levels appear to be specific biochemical indicators of glial and neuronal cell number and viability. Levels of these cell-specific isoenzymes may therefore prove useful in quantitating neuropathological changes in various neurological disorders.

摘要

在亨廷顿病患者以及年龄和性别匹配的对照者大脑的基底神经节和大脑皮质组织中，测定了烯醇化酶细胞特异性脑同工酶的水平。亨廷顿病患者基底神经节中神经元特异性烯醇化酶（NSE）水平平均降低45%，而胶质细胞特异性形式的烯醇化酶，即非神经元烯醇化酶（NNE），则无显著改变。相比之下，与对照组相比，亨廷顿病患者大脑皮质组织中NSE水平保持不变，而NNE水平显著升高。NNE和NSE水平似乎是胶质细胞和神经元细胞数量及活力的特异性生化指标。因此，这些细胞特异性同工酶的水平可能有助于量化各种神经系统疾病中的神经病理变化。